Description

• General description: An excellent derivative for the synthesis by Fmoc SPPS of branched peptides and peptides modified at the lysine side-chain [1], and for the construction of templates and multifunctionalized resins for combinatorial synthesis.The side-chain Mmt group can be selectively removed in the same manner as Mtt with 1% TFA in DCM [2,3,4] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) [5]. Alternatively, it can be removed under milder conditions with AcOH/TFE/DCM (1:2:7) [1], leaving Mtt intact. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] S. Matysiak, et al. (1998) Tetrahedron Lett., 39, 1733. [2] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283. [3] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488. [4] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264. [5] K. Barlos, personal communication.
• Application: Synthesis and evaluation of antifungal peptoid derivatives against Cryptococcus neoformans: For drug discovery chemists, this research highlights the use of Fmoc-Lys(Mmt)-OH in synthesizing peptoid derivatives with potential antifungal properties, demonstrating the compound′s utility in developing new antimicrobial agents (M Wassom, 2022).
• Linkage: Replaces: 04-12-1232
• Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.0 % (a/a)Purity (TLC(0009)): ≥ 95 %Assay (HPLC, area%): ≥ 95.0 % (a/a)Assay (acidimetric): ≥ 80.0 %Water (K. F.): ≤ 2.0 %To see the solvent systems used for TLC of Novabiochem® products please click here.Product is stabilised with up to 20% diisopropylether upon drying.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany