Description

• General description: COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3]. Associated Protocols and Technical ArticlesGuide to Selection of Coupling ReagentsLiterature references[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404. [2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6. [3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.
• Application: Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).
• Analysis Note: Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testAssay (HPLC, area%): ≥ 99.0 % (a/a)Solubility (10% in acetonitrile): clear
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany