Description

• General description: A highly versatile reagent for the solid phase immobilization of alcohols [1,2,3]; carboxylic, phosphonic and sulfonic acids [4]; thiols and thioacids [4]; and phenols [5]. In contrast to the analogous bromide resin which is loaded under basic conditions, derivatization of this support is achieved under acidic conditions, making it compatible with base-sensitive compounds such as Fmoc-amino alcohols. Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins Literature references [1] S. Hanessian & X. Fang (1998) Tetrahedron Lett., 39, 733. [2] A. Bianco, et al. (2000) J. Comb. Chem., 2, 681.[3] A. Kamal, et al. (2002) Tetrahedron Lett., 43, 2103. [4] C. W. Phoon, et al. (1998) Tetrahedron Lett., 39, 7959. [5] A. Kamal, et al. (2001) Tetrahedron Lett., 42, 6969.
• Linkage: Replaces: 01-64-0314
• Analysis Note: Color (visual): slight yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis after derivatization with thioacetic acid): 0.60 - 1.20 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany