CENP-F/Mitosin Polyclonal Antibody, Bethyl Laboratories

Description

• The recommended shelf life for this product is 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Gorilla, Chimpanzee and Northern white-cheeked gibbon This gene encodes a protein that associates with the centromere-kinetochore complex
• The protein is a component of the nuclear matrix during the G2 phase of interphase
• In late G2 the protein associates with the kinetochore and maintains this association through early anaphase
• It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded
• The localization of this protein suggests that it may play a role in chromosome segregation during mitotis
• It is thought to form either a homodimer or heterodimer
• Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.