MCPT-1 Recombinant Rabbit Monoclonal Antibody (43), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Mouse MCPT-1/MCP-1
• MCPT-1 is the only chymase expressed by intestinal mucosal mast cells, which are found in the intestinal epithelium
• Although it is expressed constitutively and is detectable in the sera of normal mice, parasites in the gut cause systemic levels to increase dramatically within two days and peak at two weeks following infection
• It plays an important role in host defense against intestinal parasites, as mice deficient in MCPT-1 display delayed response upon infection
• Elevated MCPT-1 levels are also observed during intestinal allergic hypersensitivity reactions
• The mechanism of its action is not fully understood, although it is believed to increase intestinal permeability similarly to rMCPT-II, possibly by cleaving the proteins at tight junctions between cells.