N3-Lys(Fmoc)-OH

Description

• General description: A useful tool for the synthesis of branched, side-chain modified, cyclic peptides and peptide tools for click chemistry by Fmoc SPPS. The side-chain azido group is completely stable to piperidine and TFA, but can be readily converted to an amine on the solid phase or in solution by reduction with thiols or phosphines. Associated Protocols and Technical Articles Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS Guide to Selection of Orthogonally -Protected Building Blocks for Fmoc SPPS Literature references [1] M. Meldal, et al. (1997) Tetrahedron Lett., 38, 2531. [2] J. T. Lundquist & J. C. Pelletier (2001) Org. Lett., 3, 781. [3] N. Nepomniaschiy, et al. (2008) Org. Lett., 10, 5243.
• Analysis Note: Colour (visual): white to off whiteAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.5 % (a/a)Purity (HPLC): ≥ 98.0 % (a/a)Purity (TLC): ≥ 98 %Solubility (1 mmole in 2 ml DMF): clear solubleEthyl acetate (HS-GC): ≤ 0.5 %Acetate (IC): ≤ 0.1 %To see the solvent systems used for TLC of Novabiochem® products please click here.
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany