NovaSyn®TGR resin

Description

• General description: An excellent acid labile support for Fmoc continuous flow and batch synthesis of peptide amides. This resin is prepared from 90 μm NovaSyn TG amino resin by derivatization with the modified Rink linker. It is supplied without Fmoc protection of the linker benzhydrylamine group as this has been found to improve stability. Cleavage is effected with 95% TFA.Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins
• Application: An overview of chemical synthesis of antiviral peptides: This study discusses the use of NovaSyn®TGR resin, among others, for peptide synthesis using the Fmoc strategy, particularly highlighting its application in synthesizing antiviral peptides. (Maharani & Muhajir, 2021).
• Linkage: Replaces: 01-64-0060
• Analysis Note: Color (visual): pale yellow to yellow to beigeAppearance of substance (visual): beadsLoading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/gSwelling Volume (in DMF): lot specific resultThe base resin is a PEG-PS copolymer (90 µm) functionalised with the modified Rink linker.
• Legal Information: NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany