Description

• General description: A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage [1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides [3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4] .Associated Protocols and Technical ArticlesProtocols for Loading of Peptide Synthesis Resins
• Application: Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023). Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017). A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).
• Linkage: Replaces: 01-64-0059
• Analysis Note: Color (visual): white to light yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/gSwelling Volume (in DMF): lot specific resultSwelling Volume (in CH₂Cl₂): lot specific resultTotal swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/gTotal swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/gThe polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany