DFPE polystyrene

Description

• General description: This resin is prepared under conditions optimized to minimize styrene formation during attachment of the linker to the functionalized ethylpolystyrene support. This high substitution, coupled with the lack of amide bonds and potentially acid-sensitive benzylic linkages, makes this support the preferred choice of SPOS of secondary sulfonamides and carboxamides. Applications of FMPE include aminofurazanopyrazines [1] and peptide agonists for human orphan receptor BRS-3 [2].Associated Protocols and Technical Articles Protocols for Loading of Peptide Synthesis Resins Literature referencesLiterature references [1] B. Dörner & P. White in ′Peptides 1998, Proc. 25th European Peptide Symposium′, S. Bajusz & F. Hudecz (Eds), Budapest, Akadémiai Kiadó, 1999, pp. 90. [2] M. Grimstrup & F. Zaragoza (2002) Eur. J. Org. Chem., 2953. [3] K. J. Jensen, et al. (1998) J. Am. Chem. Soc., 120, 5441. [4] M. del Fresno, et al. (1998) Tetrahedron Lett., 39, 2639. [5] N. S. Gray, et al. (1997) Tetrahedron Lett., 38, 1161.[6] J. Alsina, et al. (1999) Chem. Eur. J., 5, 2787.[7] J. F. Tolborg & K. J. Jensen (2000) Chem. Commun., 147. [8] A. E. Fenwick, et al. (2001) Bioorg. Med. Chem. Lett., 11, 195. [9] J. Giovannoni, et al. (2001) Tetrahedron Lett., 42, 5389. [10] J. T. Bork, et al. (2003) Org. Lett., 5, 117. [11] C. P. Holmes, Paper ORGN 383 presented at the 213th National Meeting of the American Chemical Society, San Francisco, 1997. [12] C. Pégurier, et al. (2000) Bioorg. Med. Chem., 8,163. [13] T. F. Herpin, et al. (2000) J. Comb. Chem., 2, 513.
• Linkage: Replaces: 01-64-0360
• Analysis Note: Color (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (determined by elemental analysis of sulfur after derivatization with tosylhydrazide): 0.50 - 1.10 mmol/gSwelling Volume (in DMF): lot specific resultThe polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh
• Legal Information: Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany